"apo(a) isoforms and lp(a) concentration in predicting risk for coronary artery disease: a study in men <55 years of age "
نویسندگان
چکیده
lipoprotein (a) [lp (a) is formed by assembly of ldl-particles and the carbohydrate rich protein, apolipoprotein (a) [apo (a)]. elevated plasma lp (a) levels are an independent predictor of the development of premature coronary artery disease (cad), but is not clear whether the apo (a) isoform plays on additional and independent role or not. to investigate the possible effect of apo (a) isoform on premature cad (in patients < 55 years of age), we have analyzed apo (a) isoforms, lp (a) level and their relation with many recognized cad risk factors, in 60 male patients with angiographically defined cad and in 60 male control with no angiographic evidence of cad. the results show elevated lp (a) concentration (29.4±16.1, vs. 16.5±9.9 p<0.01) and frequency of s2 isoform (31.7%, vs. 6.7% p<0.01) and b isoform (10% vs. 1.7% p<0.01) in patients with premature cad. patients with s2 isoform exhibited significantly higher plasma lp(a) concentration than control subject with the same isoform (39.8±15.9 vs. 20.5±6.9, p<0.05), but patient with b isoform exhibited no significant lp(a) concentration as compared to the controls (49.5±9.46 vs. 45). in addition, all patients had a low frequency of s4 and null isoforms. the distribution of apo (a) lsoforms was significantly shifted towards small isoform size (band s2) in the cad as compared to the controls. this study provides evidence that cad patient < 55 years of age have a different pattern of apo (a) isoforms than controls, and therefore apo (a) isoform may play an important role in predicting premature cad.
منابع مشابه
Left Main Coronary Artery Disease: traditional risk factors in a study from northwest of Iran
Background & Aims: Significant left main coronary artery disease (LMCAD) is found in 3 to 6 percent of all patients who undergo coronary arteriography. LMCAD usually requires an emergent surgery that has a higher rate of mortality and complications. The risk factors of left main involvement in previous studies are controversial. The aim of this study was to determine the traditional risk factor...
متن کاملa contrastive study of rhetorical functions of citation in iranian and international elt scopus journals
writing an academic article requires the researchers to provide support for their works by learning how to cite the works of others. various studies regarding the analysis of citation in m.a theses have been done, while little work has been done on comparison of citations among elt scopus journal articles, and so the dearth of research in this area demands for further investigation into citatio...
the role of type-d personality, social support and self-compassion in prediction of health behaviors in coronary heart disease patients
نظر به اهمیت و تاثیر روزافزون عوامل روانی – اجتماعی در سلامت جسمی و تاثیر عوامل روان شناختی در بروز بیماریهای مختلف از جمله بیماریهای قلبی و عروقی این پژوهش با هدف کلی بررسی ارتباط تیپ شخصیتی d ، حمایت اجتماعی و خود دلسوزی در پیش بینی رفتارهای بهداشتی بیماران کرونر قلبی و تعیین تفاوت بین بیماران کرونر قلبی با و بدون جراحی و افراد سالم در این متغیرها و رفتارهای بهداشتی آنان، انجام گرفت. جامعه آ...
15 صفحه اولCoronary Artery Disease Risk Factors in Patients Undergoing Coronary Artery Bypass Graft Surgery
Introduction: Nowadays, with the advancement of technology and industrial life, the prevalence of heart diseases including coronary artery diseases has considerably increased. Coronary artery diseases are one of the most common and serious diseases that threaten human life. Methods: The present study is a comparative-descriptive research. The statistical ...
متن کاملthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
acta medica iranicaجلد ۳۸، شماره ۴، صفحات ۲۱۴-۲۱۸
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023